Pituitary disorders

The monograph “Pituitary Disorders”provides a comprehensive and up-to-date overview of the anatomy, physiology, pathophysiology, diagnosis, and treatment of pituitary diseases, with particular emphasis on recent advances in molecular biology, endocrinology, and neurosurgery. It covers disorders affecting the pituitary gland, including sellar masses, functional and non-functioning pituitary tumors, prolactinomas, acromegaly, Cushing’s disease, TSH-secreting tumors, and pituitary carcinomas, presenting current classifications as well as the genetic and epigenetic mechanisms underlying tumor development and their clinical implications. Special attention is given to diagnostic algorithms integrating clinical, biochemical, radiological, and histopathological findings, enabling more accurate diagnosis and individualized therapeutic strategies. The monograph reviews current medical, surgical, and radiotherapeutic treatment options, including modern endoscopic techniques, biological therapies, and principles of long-term patient follow-up. It emphasizes the importance of a multidisciplinary approach involving endocrinologists, neurosurgeons, radiologists, pathologists, and other specialists in the management of patients with pituitary diseases. Particular focus is placed on the application of the latest World Health Organization classification, the role of molecular biomarkers in assessing tumor biological behavior, and the prospects for personalized medicine. This monograph is intended for medical students, residents, endocrinologists, internists, neurosurgeons, and other healthcare professionals as a reliable source of contemporary scientific knowledge and practical guidance for the diagnosis, treatment, and long-term management of patients with pituitary diseases.